Publication
Research Articles
2024
28. Wyler SC, Gahlot S, Bideyan L, Yip C, Dushime J, Chen B, Lee JJ, Tinajero A, Limboy C, Bordash S, Heaselgrave SR, Nguyen TN, Lee S, Bookout A, Lantier L, Fowlkes JL, You YJ, Fujikawa T* (corresponding author), Elmquist JK. LCoRL regulates growth and metabolism. Endocrinology. 2024 Oct 28:bqae146. doi: 10.1210/endocr/bqae146. PMID: 39467326
27. Reynolds RP, Fan RR, Tinajero A, Luo X, Huen SC, Fujikawa T, Lee S, Lemoff A, Mountjoy KG, Elmquist JK. Alpha-melanocyte-stimulating hormone contributes to an anti-inflammatory response to lipopolysaccharide. Mol Metab. 2024 Jul 9;87:101986. doi:10.1016/j.molmet.2024.101986. PMID: 38992428
26. Tan S, Santolaya JL, Wright TF, Liu Q, Fujikawa T, Chi S, Bergstrom CP, Lopez A, Chen Q, Vale G, McDonald JG, Schmidt A, Vo N, Kim J, Baniasadi H, Li L, Zhu G, He TC, Zhan X, Obata Y, Jin A, Jia D, Elmquist JK, Sifuentes-Dominguez L, Burstein E. Interaction between the gut microbiota and colonic enteroendocrine cells regulates host metabolism. Nat Metab. 2024 Jun;6(6):1076-1091. doi: 10.1038/s42255-024-01044-5. Epub 2024 May 22. PMID: 38777856
2023
25. Yoshida T, Fujitani M, Farmer S, Harada A, Shi Z, Lee JJ, Tinajero A, Singha AK, Fujikawa T. VMHdm/cSF-1 Neuronal Circuits Regulate Skeletal Muscle PGC1-alpha via the Sympathoadrenal Drive. Mol Metab. 2023:101792. Epub 20230824. doi: 10.1016/j.molmet.2023.101792. PMID: 37633515
2022
24. Katsumura S., Siddiqui N., Goldsmith M.R., Cheah J.H., Fujikawa T., Minegishi G., Yamagata A., Yabuki Y., Kobayashi K., Shirouzu M., Inagaki T., Huang T.H., Musi N., Topisirovic I., Larsson O., Morita M. Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure. Cell Metab. 2022 Apr 5;34(4):564-580.e8. doi: 10.1016/j.cmet.2022.03.005. PMID: 35385705
Prior to 2022
23. Castorena C.M., Caron, A., Michael, N.J., Ahmed, N.I., Arnold, A.G., Lee, J., Lee, C., Limboy, C., Tinajero, A.S., Grainer, M., Wang, S., Horton, J.D., Holland, W.L., Lee, S., Liu, C., Fujikawa, T., Elmquist, J.K. CB1Rs in VMH Neurons Regulate Glucose Homeostasis but not Body Weight. Am J Physiol Endocrinol Metab (2021) : PMID: 34097543
22. Singha, A., Palavicini, JP., Pan, M., Farmer, S., Sandoval, D., Han, X., Fujikawa,T. Leptin Receptors in RIP-Cre25Mgn neurons Mediate Anti-Dyslipidemia Effects of Leptin in Insulin-Deficient Mice. Frontiers Endocrinology (2020), 2020 Sep 23;11:588447. PMID: 33071988
21. Amoasii, L., Sanchez-Ortiz, E., Fujikawa, T., Elmquist, J.K., Bassel-Duby, R., Olson, E.O. NURR1 activation in skeletal muscle controls systemic energy homeostasis. Proc Natl Acad Sci U S A., 2019 May 20. PMID: 31110021
20. Fujikawa, T., Choi, Y.H., Donate, J., Kohno, D., Lee, C.E., Elias, C.F., Lee, S., Kim, K.W. P110β in the ventromedial hypothalamus regulates glucose and energy metabolism. Experimental & Molecular Medicine, 2019 Apr 26;51(4):52. PMID: 31028248
19. Singha, A.K.*, Yamaguchi, J.*, Gonzalez, N.S., Ahmed, N., Toney, G.M., Fujikawa, T. Glucose-Lowering by Leptin in the Absence of Insulin Does Not Fully Rely on the Central Melanocortin System in Male Mice. Endocrinology, 2019 Jan 29, PMID: 30698681 *co-first author
18. Peri-Okonny, P.A., Baskin, K.K., Iwamoto, G, Mitchell, J.H., Smith, S.A., Kim, H.K., Szweda, L.I., Bassel-Duby, R., Fujikawa, T., Castorena, C.M., Richardson, J., Shelton, J.M., Ayers, C., Berry, J.D., Malladi, V.S., Hu, M.C., Moe, O.W., Scherer, P.E., Vongpatanasin, W. High-Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice. Circulation (2019), Jan 7 PMID: 30612451
17. Caron, A., Dungan-Lemko, H.M., Castorena, C.M., Fujikawa, T., Lee, S., Lord, C.C., Ahmed, N., Lee C.E., William L Holland, L.W., Liu, C. and Elmquist, J.K. LEPRs-expressing POMC neurons coordinate metabolic responses to fasting via suppression of leptin levels. eLife (2018), Mar 12;7 PMID: 29528284
16. Fujikawa, T., Castorena, C.M., Pearson, M., Kusminski, C.M., Ahmed, N., Battiprolu, P.K., Kim, K.W., Lee, S., Hill, J.A., Scherer, P.E., Holland, L.W., and Elmquist, K.J., SF-1 Expression in the Hypothalamus is Required for Beneficial Metabolic Effects of Exercise. eLife, Nov 22;5 (2016). PMID: 27874828
15. Anderson, G.A., Ramadori, G., Ioris, M.R., Galiè, M., Berglund, D.E., Coate, C. K., Fujikawa, T., Pucciarelli, S., Moreschini, B., Amici, A., Andreani, C., and Coppari, R., Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6. Molecular metabolism, (2015) PMID: 26629408
14. Williams, K.W., Liu, T., Kong, X., Fukuda, M., Deng, Y., Berglund, E.D., Deng, Z., Gao, Y., Liu, T., Sohn, J.-W., Jia, L., Fujikawa, T., Kohno, D., Sccotte, M., Lee, S., Lee, S., Sun, K., Chang, Y., Scherer, P.E., and Elmquist, J.K., Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis. Cell metabolism, (2014) 20, 471-482. PMID: 25017942
13. Asterholm, I.W., Rutkowski, J.M., Fujikawa, T., Cho, Y.R., Fukuda, M., Tao, C., Wang, Z.V., Gupta, R.K., Elmquist, J.K., and Scherer, P.E. (2014). Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice. Diabetologia, (2014) 57, 1209-1218. PMID: 24623101
12. Fujikawa, T., Berglund, E.D., Patel, V.R., Ramadori, G., Vianna, C.R., Vong, L., Thorel, F., Chera, S., Herrera, P.L., Lowell, B.B., et al. (2013). Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin. Cell metabolism 18, 431-444. PMID: 24011077
11. Yamada, H., Iwaki, Y., Kitaoka, R., Fujitani, M., Shibakusa, T., Fujikawa, T., Matsumura, S., Fushiki, T., and Inoue, K. (2012). Blood lactate functions as a signal for enhancing fatty acid metabolism during exercise via TGF-beta in the brain. J Nutr Sci Vitaminol (Tokyo) 58, 88-95. PMID: 22790566
10. Ramadori, G., Fujikawa, T., Anderson, J., Berglund, E.D., Frazao, R., Michan, S., Vianna, C.R., Sinclair, D.A., Elias, C.F., and Coppari, R. (2011). SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance. Cell metabolism 14, 301-312. PMID: 21907137
9. Miyaki, T., Fujikawa, T., Kitaoka, R., Hirano, N., Matsumura, S., Fushiki, T., and Inoue, K. (2011). Noradrenergic projections to the ventromedial hypothalamus regulate fat metabolism during endurance exercise. Neuroscience 190, 239-250. PMID: 21640797
8. Ramadori, G., Fujikawa, T., Fukuda, M., Anderson, J., Morgan, D.A., Mostoslavsky, R., Stuart, R.C., Perello, M., Vianna, C.R., Nillni, E.A., et al. (2010). SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. Cell metabolism 12, 78-87. PMID: 20620997
7. Kitaoka, R., Fujikawa, T., Miyaki, T., Matsumura, S., Fushiki, T., and Inoue, K. (2010). Increased Noradrenergic Activity in the Ventromedial Hypothalamus during Treadmill Running in Rats. J Nutr Sci Vitaminol (Tokyo) 56, 185-190. PMID: 20651459
6. Fujikawa, T., Fujita, R., Iwaki, Y., Matsumura, S., Fushiki, T., and Inoue, K. (2010). Inhibition of fatty acid oxidation activates transforming growth factor-beta in cerebrospinal fluid and decreases spontaneous motor activity. Physiology & behavior 101, 370-375. PMID: 20619281
5. Fujikawa, T., Chuang, J.C., Sakata, I., Ramadori, G., and Coppari, R. (2010). Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice. Proc Natl Acad Sci U S A 107, 17391-17396. PMID: 20855609
4. Ramadori, G., Gautron, L., Fujikawa, T., Vianna, C.R., Elmquist, J.K., and Coppari, R. (2009). Central administration of resveratrol improves diet-induced diabetes. Endocrinology 150, 5326-5333. PMID: 19819963
3. Matsumura, S., Shibakusa, T., Fujikawa, T., Yamada, H., Matsumura, K., Inoue, K., and Fushiki, T. (2008). Intracisternal administration of transforming growth factor-beta evokes fever through the induction of cyclooxygenase-2 in brain endothelial cells. American journal of physiology Regulatory, integrative and comparative physiology 294, R266-275. PMID: 17959708
2. Matsumura, S., Shibakusa, T., Fujikawa, T., Yamada, H., Inoue, K., and Fushiki, T. (2007). Increase in transforming growth factor-beta in the brain during infection is related to fever, not depression of spontaneous motor activity. Neuroscience 144, 1133-1140. PMID: 17156928
1. Fujikawa, T., Matsumura, S., Yamada, H., Inoue, K., and Fushiki, T. (2007). Transforming growth factor-beta in the brain enhances fat oxidation via noradrenergic neurons in the ventromedial and paraventricular hypothalamic nucleus. Brain Res 1173, 92-101. PMID: 17765878
Review/Research Perspective/Comments
6. Hwang E, Portillo B, Grose K, Fujikawa T, and Williams KW. Exercise-induced hypothalamic neuroplasticity: Implications for energy and glucose metabolism. Mol Metab. 2023 May 31 PMID: 37268247
5. Fujikawa, T. Central Regulation of Glucose Metabolism in an Insulin-Dependent and -Independent Manner. J Neuroendocrino, (2021) PMID 33599044
4. Fujikawa, T., Castorena, C.M., Lee, S., and Elmquist, J.K., The Hypothalamic Regulation of Metabolic Adaptations to Exercise. J Neuroendocrino, (2017) PMID 28887871
3. Fujikawa, T*. and Coppari, R*. Living without insulin: the role of leptin signaling in the hypothalamus. Front Neurosci, (2015). *co-corresponding author PMID: 25870537
2. Fujikawa, T*. and Coppari, R*. Hypothalamic-mediated control of glucose balance in the presence and absence of insulin. Aging, (2014)*co-corresponding author PMID: 24589844
1. Choi, Y.H.*, Fujikawa, T.*(*co-first author), Lee, J., Reuter, A., and Kim, K.W. (2013). Revisiting the Ventral Medial Nucleus of the Hypothalamus: The Roles of SF-1 Neurons in Energy Homeostasis. Front Neurosci 7, 71. PMID: 23675313